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Medline ® Abstract for Reference 7

of 'Panniculitis: Recognition and diagnosis'

Lupus panniculitis: clinical perspectives from a case series.
Martens PB, Moder KG, Ahmed I
J Rheumatol. 1999;26(1):68.
OBJECTIVE: To review clinical and laboratory features of lupus panniculitis from a large group of patients.
METHODS: Retrospective chart review of patients diagnosed with lupus panniculitis at a tertiary medical center from 1976 to 1993.
RESULTS: Lupus panniculitis occurred most frequently in adult women. Skin lesions involved proximal extremities, trunk, face, and scalp. Only 4 of 40 patients fulfilled criteria for systemic lupus erythematosus (SLE), and, other than positive antinuclear antibodies, a paucity of other autoantibodies was seen. Average disease duration was 6 years (range 0-38). Treatment with antimalarial agents was undertaken in most cases. Disease related morbidity (disfigurement and disability) was relatively common, but death was rare.
CONCLUSION: Lupus panniculitis is a chronic inflammatory disease of subcutaneous adipose tissue that can develop during the course of SLE, although most patients do not develop systemic lupus.
Department of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.