Overview of treatment approaches for hepatocellular carcinoma
- Eddie K Abdalla, MD
Eddie K Abdalla, MD
- Professor of Surgery
- The Lebanese American University
- Keith E Stuart, MD
Keith E Stuart, MD
- Chairman, Department of Hematology and Oncology
- Lahey Hospital and Medical Center
- Section Editors
- Kenneth K Tanabe, MD
Kenneth K Tanabe, MD
- Section Editor — Gastrointestinal Malignancies
- Professor of Surgery
- Harvard Medical School
- Richard M Goldberg, MD
Richard M Goldberg, MD
- Section Editor — Gastrointestinal Cancer
- Professor of Medicine
- The James Cancer Hospital and Solove Research Institute
- Associate Director of Outreach
- Comprehensive Cancer Center
- The Ohio State University Medical Center
Hepatocellular carcinoma (HCC) is an aggressive tumor that often occurs in the setting of chronic liver disease and cirrhosis. (See "Epidemiology and etiologic associations of hepatocellular carcinoma".) It is typically diagnosed late in its course, and the median survival following diagnosis is approximately 6 to 20 months . Although the mainstay of therapy is surgical resection, the majority of patients are not eligible because of tumor extent or underlying liver dysfunction.
Several other treatment modalities are available, including:
●Radiofrequency ablation (RFA) and microwave ablation
●Percutaneous ethanol or acetic acid ablation
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- TREATMENT ALGORITHMS FOR HCC
- TREATMENT OPTIONS
- Surgical resection
- Liver transplantation
- Radiofrequency ablation
- TACE plus RFA
- Percutaneous ethanol or acetic acid ablation
- Transarterial chemoembolization
- Radiation therapy and stereotactic body radiotherapy
- - Radioembolization
- Systemic therapy
- - Molecularly targeted therapy: Sorafenib
- - Cytotoxic chemotherapy
- INFORMATION FOR PATIENTS