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Overview of the treatment of chronic myeloid leukemia

Authors
Robert S Negrin, MD
Charles A Schiffer, MD
Section Editor
Richard A Larson, MD
Deputy Editor
Alan G Rosmarin, MD

INTRODUCTION

Chronic myeloid leukemia (CML, chronic myelocytic or chronic myelogenous leukemia) is classified as a myeloproliferative disorder, along with polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (table 1). (See "Overview of the myeloproliferative neoplasms".)

This group of diseases shares several distinct features:

They are clonal disorders of hematopoiesis that arise in a hematopoietic stem or early progenitor cell.

They are characterized by the dysregulated production of a particular lineage of mature myeloid cells with fairly normal differentiation.

They exhibit a variable tendency to progress to acute leukemia.

                  

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Literature review current through: Nov 2016. | This topic last updated: Fri Nov 04 00:00:00 GMT 2016.
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