Overview of the treatment of chronic myeloid leukemia
- Robert S Negrin, MD
Robert S Negrin, MD
- Section Editor — Bone Marrow Transplantation
- Professor of Medicine
- Stanford University School of Medicine
- Charles A Schiffer, MD
Charles A Schiffer, MD
- Professor of Medicine and Oncology
- Barbara Ann Karmanos Cancer Institute
- Wayne State University School of Medicine
Chronic myeloid leukemia (CML, chronic myelocytic or chronic myelogenous leukemia) is classified as a myeloproliferative disorder, along with polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (table 1). (See "Overview of the myeloproliferative neoplasms".)
This group of diseases shares several distinct features:
●They are clonal disorders of hematopoiesis that arise in a hematopoietic stem or early progenitor cell.
●They are characterized by the dysregulated production of a particular lineage of mature myeloid cells with fairly normal differentiation.
●They exhibit a variable tendency to progress to acute leukemia.To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- DISEASE PHASE
- OVERVIEW OF TREATMENT OPTIONS
- Hematopoietic cell transplantation
- Tyrosine kinase inhibitors
- Other agents
- INITIAL TREATMENT
- Chronic phase
- Accelerated or blast phase
- MONITORING RESPONSE
- Schedule of evaluation
- Response criteria
- - Responses defined
- - Defining failure, suboptimal response, and optimal response
- Evaluation at loss of response
- DISCONTINUATION OF TKI THERAPY
- TREATMENT OF DISEASE RESISTANCE OR DRUG INTOLERANCE
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS