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Medline ® Abstract for Reference 54

of 'Overview of the pulmonary complications of sickle cell disease'

54
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Low daytime pulse oximetry reading is associated with nocturnal desaturation and obstructive sleep apnea in children with sickle cell anemia.
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Spivey JF, Uong EC, Strunk R, Boslaugh SE, DeBaun MR
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Pediatr Blood Cancer. 2008;50(2):359.
 
A retrospective medical record review was established to test the hypothesis that in children with sickle cell anemia (SCA), a daytime oxygen saturation (SpO(2))</=94% is associated with nocturnal desaturation with or without obstructive sleep apnea (OSA). Twenty children had a resting SpO(2)</=94% and an abnormal polysomnogram (PSG). Seven patients had OSA and thirteen patients had nocturnal desaturation. The average daytime SpO(2) correlated with the average nighttime SpO(2) (Spearman correlation coefficient = 0.453; P = 0.045). Our results indicate that in children with SCA, a daytime SpO(2)</=94% is a reasonable threshold to recommend a pulmonary evaluation, including a PSG.
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Department of Pediatrics, Washington University School of Medicine/St. Louis Children's Hospital, St. Louis, Missouri, USA.
PMID