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Medline ® Abstract for Reference 54

of 'Overview of the pulmonary complications of sickle cell disease'

Low daytime pulse oximetry reading is associated with nocturnal desaturation and obstructive sleep apnea in children with sickle cell anemia.
Spivey JF, Uong EC, Strunk R, Boslaugh SE, DeBaun MR
Pediatr Blood Cancer. 2008;50(2):359.
A retrospective medical record review was established to test the hypothesis that in children with sickle cell anemia (SCA), a daytime oxygen saturation (SpO(2))</=94% is associated with nocturnal desaturation with or without obstructive sleep apnea (OSA). Twenty children had a resting SpO(2)</=94% and an abnormal polysomnogram (PSG). Seven patients had OSA and thirteen patients had nocturnal desaturation. The average daytime SpO(2) correlated with the average nighttime SpO(2) (Spearman correlation coefficient = 0.453; P = 0.045). Our results indicate that in children with SCA, a daytime SpO(2)</=94% is a reasonable threshold to recommend a pulmonary evaluation, including a PSG.
Department of Pediatrics, Washington University School of Medicine/St. Louis Children's Hospital, St. Louis, Missouri, USA.