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Medline ® Abstract for Reference 74

of 'Overview of neurologic complications of non-platinum cancer chemotherapy'

Phantom limb pain as a manifestation of paclitaxel neurotoxicity.
Khattab J, Terebelo HR, Dabas B
Mayo Clin Proc. 2000;75(7):740.
Paclitaxel is a chemotherapeutic agent with activity directed against several malignancies. It has multiple adverse effects including neurotoxicity. We describe 2 patients with prior amputation who experienced phantom limb pain (PLP) after receiving paclitaxel therapy. A third patient experienced disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition after receiving paclitaxel. This unique syndrome should be identified as a direct causal effect of paclitaxel. In this report, we review the pathophysiology of PLP and treatment options. Physicians should be aware that PLP can occur after initiation of paclitaxel.
Section of Medical Oncology, Providence Hospital, Southfield, Mich. 48075, USA.