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Medline ® Abstract for Reference 73

of 'Overview of neurologic complications of non-platinum cancer chemotherapy'

Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma.
Rook J, Rosser T, Fangusaro J, Finlay J
Pediatr Blood Cancer. 2008;50(3):699.
Paclitaxel is an antineoplastic agent that is used in the treatment of a variety of solid tumors. Dose-limiting side effects of myelosuppression and peripheral neuropathy are well known. Paclitaxel has minimal penetration of the blood-brain barrier and central nervous system side effects are rare. However, transient encephalopathy following paclitaxel infusion has been described in adults but not in children. We present the case of a 14-year-old female with a recurrent suprasellar germinoma who developed an acute encephalopathy 4-6 hr following paclitaxel infusion.
Department of Pediatrics, Loma Linda University Children's Hospital, Loma Linda University School of Medicine, Loma Linda, California, USA.