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Medline ® Abstract for Reference 65

of 'Overview of neurologic complications of non-platinum cancer chemotherapy'

BMI, Lifestyle Factors and Taxane-Induced Neuropathy in Breast Cancer Patients: The Pathways Study.
Greenlee H, Hershman DL, Shi Z, Kwan ML, Ergas IJ, Roh JM, Kushi LH
J Natl Cancer Inst. 2017;109(2) Epub 2016 Oct 28.
BACKGROUND: Lifestyle factors may be associated with chemotherapy-induced peripheral neuropathy (CIPN). We examined associations between body mass index (BMI) and lifestyle factors with CIPN in the Pathways Study, a prospective cohort of women with invasive breast cancer.
METHODS: Analyses included 1237 women who received taxane treatment and provided data on neurotoxicity symptoms. Baseline interviews assessed BMI (normal:<25 kg/m(2); overweight: 25-29.9 kg/m(2); obese:≥30 kg/m(2)), moderate-to-vigorous physical activity (MVPA) (low:<2.5; medium: 2.5-5; high:>5 hours/week) and fruit/vegetable intake (low:<35 servings/week; high:≥35 servings/week). Baseline and six-month interviews assessed antioxidant supplement use (nonuser, discontinued, continued user, initiator). CIPN was assessed at baseline, six months, and 24 months using the Functional Assessment of Cancer Therapy-Taxane Neurotoxicity (FACT-NTX); a 10% decrease was considered clinically meaningful.
RESULTS: At baseline, 65.6% of patients in the sample were overweight or obese, 29.9% had low MVPA, 57.5% had low fruit/vegetable intake, and 9.5% reported antioxidant supplement use during treatment. In multivariable analyses, increased CIPN was more likely to occur in overweight (odds ratio [OR]= 2.37, 95% confidence interval [CI]= 1.19 to 4.88) and obese patients (OR = 3.21, 95% CI = 1.52 to 7.02) compared with normal weight patients at 24 months and less likely to occur in patients with high MVPA compared with those with low MVPA at six (OR = 0.56, 95% CI = 0.34 to 0.94) and 24 months (OR = 0.43, 95% CI = 0.21 to 0.87). Compared with nonusers, patients who initiated antioxidant use during treatment were more likely to report increased CIPN at six months (OR = 3.81, 95% CI = 1.82 to 8.04).
CONCLUSIONS: Obesity and low MVPA were associated with CIPN in breast cancer patients who received taxane treatment.
Mailman School of Public Health (HG, DLH, ZS), Herbert Irving Comprehensive Cancer Center (HG, DLH), and College of Physicians and Surgeons (DLH), Columbia University, New York, NY; Division of Research, Kaiser Permanente Northern California, Oakland, CA (MLK, IJE, JMR, LHK). hg2120@columbia.edu.