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Medline ® Abstract for Reference 238

of 'Overview of neurologic complications of non-platinum cancer chemotherapy'

5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma.
Formica V, Leary A, Cunningham D, Chua YJ
Cancer Chemother Pharmacol. 2006;58(2):276. Epub 2005 Dec 7.
PURPOSE: Capecitabine is a relatively new oral fluoropyrimidine currently licensed for the treatment of colorectal and breast cancer.
RESULTS: It has the advantage of oral administration with good tolerability and comparable activity to intravenous 5-fluorouracil. Central neurotoxicity has been described in 5-fluorouracil-treated patients but there is little data regarding capecitabine. We report here a case of reversible capecitabine-induced encephalopathy progressing to coma.
DISCUSSION: Literature on fluoropyrimidine-related neurotoxicity will also be reviewed and possible mechanisms of the drug or its metabolites crossing the blood-brain barrier will be discussed.
Department of Medicine, Royal Marsden Hospital, Sutton, Surrey SM2 5PT, UK.