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Medline ® Abstract for Reference 229

of 'Overview of neurologic complications of non-platinum cancer chemotherapy'

Brain infarction following 5-fluorouracil and cisplatin therapy.
El Amrani M, Heinzlef O, Debroucker T, Roullet E, Bousser MG, Amarenco P
Neurology. 1998;51(3):899.
Five patients with oropharyngeal cancer treated with 5-fluorouracil and cisplatin had ischemic stroke within 2 to 5 days after the drug infusion. This occurred during the second course of chemotherapy in three patients, and during the third course in two patients. There may be a relation between treatment and brain infarction because 1) there was no other cause identified despite extensive tests, including postmortem examination in one patient; 2) there was a short delay between treatment infusion and stroke; and 3) there was a similar pattern of ischemic stroke after the second or third course of chemotherapy.
Department of Neurology, Saint-Antoine Hospital, Paris, France.