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Medline ® Abstract for Reference 226

of 'Overview of neurologic complications of non-platinum cancer chemotherapy'

226
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Optic neuropathy in cancer patients. Report of a case possibly related to 5 fluorouracil toxicity and review of the literature.
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Delval L, Klastersky J
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J Neurooncol. 2002;60(2):165.
 
We report the case of a 72-year-old woman suffering from bone metastatic breast cancer and treated with continuous intravenous 5 fluorouracil (5FU) chemotherapy, who presented with a bilateral asymmetric anterior optic neuropathy (ON). A deficiency of dihydropyrimidine dehydrogenase (DPD) was documented. Patients with DPD deficiency are at increased risk for developing unusual and/or severe toxicity to 5FU. We discuss the differential diagnosis of anterior ON and we suggest that 5FU can be responsible for optic nerve toxicity in patients with DPD deficiency.
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Service de Médecine Interne et Laboratoire d'Investigations Cliniques, Centre des Tumeurs de l'UniversitéLibre de Bruxelles, Bruxelles, Belgique. ldelval@swing.be
PMID