Medline ® Abstract for Reference 210
of 'Overview of neurologic complications of non-platinum cancer chemotherapy'
Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.
Nevill TJ, Benstead TJ, McCormick CW, Hayne OA
Am J Hematol. 1989;32(4):314.
High-dose cytosine arabinoside may benefit patients with refractory acute leukemia. Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported. We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside. Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.