Medline ® Abstract for Reference 156
of 'Overview of neurologic complications of non-platinum cancer chemotherapy'
Thalidomide chemotherapy-induced peripheral neuropathy: actual status and new perspectives with thalidomide analogues derivatives.
Cundari S, Cavaletti G
Mini Rev Med Chem. 2009 Jun;9(7):760-8.
IMiDs compounds are a class of analogues of thalidomide, with greater immunomodulatory activity and a superior safety profile compared to the parent compound. They show substantial increase in potency and an interesting tolerability profile, primarily due to a decreased incidence of the most severe side effect of thalidomide, i.e. Chemotherapy-Induced Peripheral Neurotoxicity (CIPN). These novel aspects of the IMiDs compounds will be discussed.
Medical Department, Celgene S.r.l., Corso Garibaldi 86 - 20121 Milano, Italy.