Medline ® Abstract for Reference 118
of 'Overview of neurologic complications of non-platinum cancer chemotherapy'
Dose-related vincristine-induced peripheral neuropathy with unexpected off-therapy worsening.
Verstappen CC, Koeppen S, Heimans JJ, Huijgens PC, Scheulen ME, Strumberg D, Kiburg B, Postma TJ
This study describes the natural course of vincristine-induced peripheral neuropathy in patients with lymphoma (n = 114) receiving vincristine in two different dose intensities. Neuropathic changes were observed in both dose intensity groups, but the higher dose intensity group reported significantly more symptoms during therapy, whereas neurologic signs were significantly more prominent after a cumulative dose of 12 mg vincristine. Furthermore, off-therapy worsening of symptoms (24%) and signs (30%) occurred unexpectedly.
Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands.