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Overview of intravenous immune globulin (IVIG) therapy

Arthur J Silvergleid, MD
Mark Ballow, MD
Section Editors
Stanley L Schrier, MD
E Richard Stiehm, MD
Deputy Editors
Jennifer S Tirnauer, MD
Anna M Feldweg, MD


Immune globulin derived from the plasma of paid and volunteer donors is used in the treatment of an array of disorders, including primary and secondary immune deficiency states and a variety of autoimmune and inflammatory disorders.

This topic will review the indications, proposed mechanisms of action, and administration of intravenous immune globulin (IVIG).

Additional topic reviews discuss the adverse effects of IVIG therapy and the administration of immune globulin by subcutaneous and intramuscular routes. (See "Intravenous immune globulin: Adverse effects" and "Subcutaneous and intramuscular immune globulin therapy".)

The use of IVIG in the treatment of specific disease states is discussed separately. (See 'Indications' below.)


Several terms are used for immune globulin preparations according to the route of administration:

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Literature review current through: Dec 2017. | This topic last updated: Feb 23, 2016.
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