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Overview of hypertrophic cardiomyopathy management including treatment of special problems

Martin S Maron, MD
Section Editor
William J McKenna, MD
Deputy Editor
Brian C Downey, MD, FACC


Hypertrophic cardiomyopathy (HCM) is a genetically determined heart muscle disease most often (60 to 70 percent) caused by mutations in one of several sarcomere genes which encode components of the contractile apparatus. (See "Hypertrophic cardiomyopathy: Gene mutations and clinical genetic testing".)

HCM is characterized by left ventricular hypertrophy of various morphologies, with a wide array clinical manifestations and hemodynamic abnormalities. Depending in part upon the site and extent of cardiac hypertrophy, HCM patients can develop one or more of the following abnormalities:

These structural and functional abnormalities can produce a variety of symptoms, including:

  • Fatigue
  • Dyspnea
  • Chest pain
  • Palpitations
  • Presyncope or syncope


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Literature review current through: Nov 2016. | This topic last updated: Thu Dec 06 00:00:00 GMT 2012.
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