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Medline ® Abstract for Reference 17

of 'Overview of epithelial carcinoma of the ovary, fallopian tube, and peritoneum'

17
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Prognostic role of hormone receptors in ovarian cancer: a systematic review and meta-analysis.
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Zhao D, Zhang F, Zhang W, He J, Zhao Y, Sun J
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Int J Gynecol Cancer. 2013 Jan;23(1):25-33.
 
OBJECTIVE: The aim of this study was to summarize the global predicting role of hormone receptors for survival in ovarian cancer.
METHODS: Eligible studies were identified and assessed for quality through multiple search strategies. Data were collected from studies comparing overall or progression-free/disease-free/relapse-free survival in patients with elevated levels of estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2) with those in patients with lower levels. Studies were pooled, and combined hazards ratios (HRs) of ER, PR, and HER2 for survival were calculated, respectively.
RESULTS: A total of 35 studies were included for meta-analysis (23 for ER, 19 for PR, and 8 for HER2). For overall survival, the pooled HR of PR reached 0.88 [95% confidence interval (CI), 0.82-0.95], which means that elevated PR level could significantly indicate better survival. In contrast, elevated levels of HER2 could predict worse outcome with an HR of 1.41 (95% CI, 1.05-1.89). Increased level of ER was not significantly prognostic (HR, 0.94; 95% CI, 0.87-1.01). For progression-free survival/disease-free survival/recurrence-free survival, elevated PR level also had predictive value for better outcome with a pooled HR of PR of 0.80 (95% CI, 0.67-0.95). Oppositely, elevated HER2 level could predict poorer outcome with an HR of 1.55 (95% CI, 1.11-2.16). Estrogen receptor failed to predict outcome with an HR of 0.90 (95% CI, 0.78-1.03).
CONCLUSIONS: In patients with ovarian cancer, elevated level of PR predicted favorable survival, and elevated level of HER2 was associated with worse survival.
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Department of Minimally Invasive Gynecologic Surgery, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, PR China.
PMID