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Overview of chronic kidney disease-mineral bone disease (CKD-MBD)

Wajeh Y Qunibi, MD
William L Henrich, MD, MACP
Section Editor
Jeffrey S Berns, MD
Deputy Editor
Alice M Sheridan, MD


Disorders of mineral and bone metabolism are common in patients with CKD. Traditionally, these disorders have collectively been called renal osteodystrophy. However, in 2006, an international work group convened by Kidney Disease: Improving Global Outcomes (KDIGO) recommended that the term "renal osteodystrophy" be exclusively used to define bone pathology associated with CKD. Moreover, given that mineral and bone disorders contribute to CKD-associated cardiovascular disease and high mortality rates, KDIGO recommended that the new term chronic kidney disease-mineral and bone disorder (CKD-MBD) be used to describe the broader systemic disorder that occurs as a result of CKD [1,2].

CKD-MBD is defined as a systemic disorder of mineral and bone metabolism due to CKD, manifested by either one or a combination of the following three components:

Abnormalities of calcium, phosphorus, parathyroid hormone (PTH), or vitamin D metabolism

Abnormalities in bone turnover, mineralization, volume linear growth, or strength

Extraskeletal calcification


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Literature review current through: Sep 2016. | This topic last updated: Jun 17, 2015.
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