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Overview of chronic kidney disease-mineral and bone disorder (CKD-MBD)

Wajeh Y Qunibi, MD
William L Henrich, MD, MACP
Section Editor
Jeffrey S Berns, MD
Deputy Editor
Alice M Sheridan, MD


Chronic kidney disease (CKD) is commonly associated with disorders of mineral and bone metabolism, manifested by either one or a combination of the following three components:

Abnormalities of calcium, phosphorus, parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and vitamin D metabolism

Abnormalities in bone turnover, mineralization, volume linear growth, or strength

Extraskeletal calcification

The work group of the Kidney Disease: Improving Global Outcomes (KDIGO) recommended in 2006 the use of the term chronic kidney disease-mineral and bone disorder (CKD-MBD) to describe a systemic disorder that incorporates these abnormalities [1]. The work group recommended that the traditional term "renal osteodystrophy" be exclusively used to define alterations in bone morphology associated with CKD and stated that definitive diagnosis of renal osteodystrophy can only be made by bone biopsy [1,2]. Following the introduction of the term CKD-MBD, various clinical practice guidelines have recommended laboratory targets and therapeutic approaches aimed at ameliorating the consequences of this systemic disorder.


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Literature review current through: Jan 2017. | This topic last updated: Thu Jan 19 00:00:00 GMT+00:00 2017.
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