Medline ® Abstract for Reference 81
of 'Overview and comparison of the proton pump inhibitors for the treatment of acid-related disorders'
Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro.
Tuukkanen J, Väänänen HK
Calcif Tissue Int. 1986;38(2):123.
Omeprazole has been previously shown to block gastric acid secretion by specific inhibition of gastric parietal cell membrane H+-K+-ATPase. It is now demonstrated that similar concentrations of omeprazole will inhibit PGE2- and PTH-stimulated 45Ca++ release from prelabelled neonatal mouse calvariae without affecting the viability of cultured calvaria explants.