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Medline ® Abstract for Reference 81

of 'Overview and comparison of the proton pump inhibitors for the treatment of acid-related disorders'

81
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Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro.
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Tuukkanen J, Väänänen HK
SO
Calcif Tissue Int. 1986;38(2):123.
 
Omeprazole has been previously shown to block gastric acid secretion by specific inhibition of gastric parietal cell membrane H+-K+-ATPase. It is now demonstrated that similar concentrations of omeprazole will inhibit PGE2- and PTH-stimulated 45Ca++ release from prelabelled neonatal mouse calvariae without affecting the viability of cultured calvaria explants.
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PMID