Outcome of infants with bronchopulmonary dysplasia
- Ann R Stark, MD
Ann R Stark, MD
- Professor of Pediatrics
- Vanderbilt University School of Medicine
Despite important advances in perinatal care and a steady decline in mortality rates among very low birth weight (VLBW) infants (<1500 grams), bronchopulmonary dysplasia (BPD) remains a major complication of prematurity resulting in significant mortality and morbidity. The increasing rates of survival among the smallest of premature infants due to changes in antenatal and postnatal respiratory management, such as antenatal steroids and surfactant replacement, contribute to an overall increase in the incidence of BPD despite advances in the care of premature infants that reduce the risk or severity of BPD. (See "Prevention of bronchopulmonary dysplasia".)
The outcome of infants with BPD is reviewed here. Pathogenesis and clinical features, management, and potential strategies to prevent BPD are discussed separately. (See "Pathogenesis and clinical features of bronchopulmonary dysplasia" and "Management of bronchopulmonary dysplasia" and "Prevention of bronchopulmonary dysplasia".)
Different degrees of prematurity are defined by gestational age (GA), which is calculated from the first day of the mother's last period, or birth weight (BW). Data on bronchopulmonary dysplasia (BPD) is often based upon the following classification of preterm infants, categorized by birth weight as follows:
●Low birth weight (LBW) - BW less than 2500 g
●Very low birth weight (VLBW) - BW less than 1500 g
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- TRENDS OVER TIME
- PULMONARY OUTCOME
- Respiratory infection
- Asthma-like disease
- Pulmonary function
- Pulmonary artery hypertension
- Prolonged ventilation
- NEURODEVELOPMENT OUTCOME
- School age
- Neonatal practice changes
- Confounding factors
- INFORMATION FOR PATIENTS