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Medline ® Abstract for Reference 90

of 'Oral toxicity associated with chemotherapy'

[Prevention of stomatitis induced by anti-cancer drugs].
Dozono H, Nakamura K, Motoya T, Nakamura S, Shinmura R, Miwa K, Ishibashi M, Nagata Y
Gan To Kagaku Ryoho. 1989;16(10):3449.
A randomized control trial study was carried out to evaluate the effect of allopurinol mouth wash on stomatitis induced by chemotherapy in gynecologic patients. Chemotherapeutics used consisted of 5-FU+CDDP (PF) given to 10 patients and vincristine and actinomycin-D+cyclophosphamide (VAC) given to 5. Allopurinol mouth wash was prepared for patients to rinse their mouth with the solution 4-5 times daily before and after treatment with anti-cancer drugs. The Japan Society For Cancer Therapy's criteria for stomatitis were used. In the control group, stomatitis occurred in 9 of the 10 patients receiving PF therapy and in all of the 5 receiving VAC. In contrast, stomatitis was observed in only 2 of the 10 patients receiving PF therapy and 2 of the 5 VAC in the allopurinol-treated group. Allopurinol mouth wash showed a marked effect on stomatitis induced by chemotherapy.
Dept. of Gynecology, Faculty of Medicine, Kagoshima University.