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Medline ® Abstract for Reference 127

of 'Oral toxicity associated with chemotherapy'

Evaluation of the clinical behaviour of a polyvinylpyrrolidone and sodium hyalonurate gel (Gelclair) in patients subjected to surgical treatment with CO2 laser.
Hita-Iglesias P, Torres-Lagares D, Gutiérrez-Pérez JL
Int J Oral Maxillofac Surg. 2006;35(6):514. Epub 2006 Feb 23.
This experimental study was undertaken to evaluate the efficacy of Gelclair, a concentrated oral gel consisting of sodium hyalonurate and polyvinylpyrrolidone, in decreasing postoperative pain in patients subjected to surgical treatment by extirpation and/or vapourization of oral lesions with CO(2) laser. After the surgery, 60 consecutive patients (30 in control group and 30 in experimental group) were prescribed 600 mg ibuprofen 3 times per day for 4 days. In the experimental group a protocol was established for the application of 15 ml of Gelclair directly onto the wound 3 times per day, 1 h before meals, for 1 week. Spontaneous pain and pain on swallowing were evaluated using a visual analogue scale at 24 h and 7 days after the intervention. The experimental group had less spontaneous pain at 24h (P=0.000) and at 1 week (P=0.012), and also less pain on swallowing at 24 h and 1 week (P=0.029 and P=0.000, respectively) after the intervention. In conclusion, the effectiveness of the barrier mechanism that Gelclair provides improves the postoperative experience of patients who have undergone oral CO(2) laser surgery.
Department of Oral Surgery, Faculty of Dentistry, University of Seville, C/ Avicena s/n 41009, Seville, Spain.