Official reprint from UpToDate®
www.uptodate.com ©2017 UpToDate, Inc. and/or its affiliates. All Rights Reserved.

Medline ® Abstract for Reference 44

of 'Oral isotretinoin therapy for acne vulgaris'

A case of growth failure caused by 13-CIS-retinoic acid administration after bone marrow transplantation for neuroblasoma.
Inamo Y, Suzuki T, Mugishima H
Endocr J. 1999 Mar;46 Suppl:S113-5.
We report an 11-year-old girl with growth failure caused by long-term administration of 13-cis-retinoic acid after bone marrow transplantation for neuroblastoma. Her growth velocity was 1-2 cm/year after 13-cis-retinoic acid administration. Her endocrinological findings were normal except for peak growth hormone levels of 6.4 ng/ml (clonidine) and 9.7 ng/ml (arginine). IGF-1 and IGFBP-3 were normal. It is not possible to conclude that her severe growth failure was caused by partial growth hormone deficiency, but premature epiphyseal closure was seen on radiographic examination. We concluded that the growth failure was caused by pediatric cancer therapy for the musculoskeletal system but not by endocrinological disturbance.
Department of General Pediatrics, Nihon University Nerima-Hikarigaoka Hospital, Tokyo, Japan.