Medline ® Abstract for Reference 19

of 'Oral food challenges for diagnosis and management of food allergies'

19
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Fatty acid deficiency profile in children with food allergy managed with elimination diets.
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Aldámiz-Echevarría L, Bilbao A, Andrade F, Elorz J, Prieto JA, Rodríguez-Soriano J
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Acta Paediatr. 2008;97(11):1572.
 
AIM: To evaluate plasma fatty acid (FA) composition of children with food allergy undergoing elimination diets that avoided the offending antigens.
METHODS: Twenty-five children (14 male, 11 female) aged 3.8 +/- 1.6 years (range 2-7 years) affected of multiple food allergy and managed with elimination diets participated in a cross-sectional study. Results of plasma fatty acids were compared with data obtained in 61 healthy children.
RESULTS: The patients had significantly lower values for plasma content in total polyunsaturated fatty acids, omega3 polyunsaturated fatty acids and long-chain omega3 polyunsaturated fatty acids (p<0.001) and particularly, in eicosapentaenoic acid (EPA) (20:5omega3) and docosahexaenoic acid (DHA) (22:6omega3) (p<0.001). Moreover, all established indices (essential fatty acid [EFA]index ((omega3 +omega6)/(omega7 +omega9)) (p<0.001) and sufficiency of docosahexaenoic acid index (C22:6omega3/C22:5omega6) (p<0.001)) confirmed the presence of EFA deficiency.
CONCLUSION: Children with food allergy managed with restricted intake of foods such as milk, egg, fish and vegetables are at risk of developing a deficiency in EFA and particularly in omega3 long-chain polyunsaturated fatty acids, which are especially necessary for adequate growth, neurological development and cardiovascular health.
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Divisions of Metabolism, Department of Pediatrics, Hospital de Cruces, Basque University School of Medicine, Bilbao, País Vasco, Spain. luisjose.aldamiz-echevarazuara@osakidetza.net
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