Conducting an Oral Food Challenge to Peanut in an Infant

J Andrew Bird; Marion Groetch; Katrina J Allen; S Allan Bock; Stephanie Leonard; Anna H Nowak-Wegrzyn; Scott Sicherer; April Clark; David M Fleischer; Carina Venter; Brian Vickery; Michael C Young

doi:10.1016/j.jaip.2016.07.019

Conducting an Oral Food Challenge to Peanut in an Infant

J Allergy Clin Immunol Pract. 2017 Mar-Apr;5(2):301-311.e1. doi: 10.1016/j.jaip.2016.07.019. Epub 2016 Nov 9.

Authors

Affiliations

¹ Division of Pediatric Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas, Tex; Food Allergy Center, Children's Medical Center, Dallas, Tex. Electronic address: drew.bird@utsouthwestern.edu.
² Jaffe Food Allergy Institute, Division of Pediatric Allergy, Icahn School of Medicine at Mount Sinai, New York, NY.
³ Population Health, The Murdoch Children's Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Australia.
⁴ Boulder Valley Asthma and Allergy Clinic, Boulder, Colo.
⁵ Division of Pediatric Allergy & Immunology, Rady Children's Hospital San Diego, University of California, San Diego, Calif.
⁶ Food Allergy Center, Children's Medical Center, Dallas, Tex.
⁷ Department of Pediatrics, University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, Colo.
⁸ Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁹ Division of Pediatric Allergy, Immunology and Rheumatology, University of North Carolina, Chapel Hill, NC.
¹⁰ Division of Allergy and Immunology, Children's Hospital Boston, Harvard Medical School, Boston, Mass.

PMID: 27838326
DOI: 10.1016/j.jaip.2016.07.019

Abstract

Results from the Learning Early About Peanut trial and its follow-up study suggest that early peanut introduction in the diets of high-risk infants may prevent the development of peanut allergy. Allergy organizations around the world released a unified statement, the Consensus Communication on Early Peanut Introduction and the Prevention of Peanut Allergy in High Risk Infants, in response to results from the Learning Early About Peanut trial, which recommends early introduction of peanut into the diet of those children at greatest risk of development of peanut allergy. As a result, it is expected that practicing allergists will experience an increased demand to perform an oral food challenge (OFC) in infants. Allergists often perform OFCs; however, conducting an OFC in an infant creates unique circumstances that have not been considered in previously published OFC guideline documents. The purpose of this workgroup report is to provide guidance to practitioners regarding the proper approach for conducting a peanut challenge in an infant.

Keywords: Early introduction; Food allergy; Infant; LEAP; Oral food challenge; Peanut allergy.

Publication types

Practice Guideline

MeSH terms

Administration, Oral
Allergens / immunology*
Arachis / immunology*
Consensus Development Conferences as Topic
Diet
Humans
Immunization / methods*
Infant
Infant, Newborn
Peanut Hypersensitivity / immunology*
Peanut Hypersensitivity / prevention & control*

Substances

Allergens