Optic pathway glioma
- Lawrence D Recht, MD
Lawrence D Recht, MD
- Professor of Neurology
- Stanford University School of Medicine
- Section Editors
- Jay S Loeffler, MD
Jay S Loeffler, MD
- Section Editor — Neurooncology
- Professor of Radiation Oncology
- Harvard Medical School
- Patrick Y Wen, MD
Patrick Y Wen, MD
- Section Editor — Neurooncology
- Professor of Neurology
- Harvard Medical School
- Amar Gajjar, MD
Amar Gajjar, MD
- Section Editor — Pediatric Neurooncology
- Scott and Tracie Hamilton Endowed Chair
- Director, Division of Neuro Oncology
- Co Leader Neurobiology and Brain Tumor Program
- Co Chair and Member, Department of Oncology
- St Jude Children’s Research Hospital
- Evelyn A Paysse, MD
Evelyn A Paysse, MD
- Section Editor — Pediatric Ophthalmology
- Professor of Ophthalmology and Pediatrics
- Baylor College of Medicine
Optic pathway gliomas (OPG) (also referred to as optic gliomas) are low-grade astrocytic tumors that occur in the optic nerve, chiasm, or both. (See "Classification and pathologic diagnosis of gliomas".)
The classification, diagnosis, natural history, and management of OPGs will be reviewed here.
Optic pathway gliomas account for approximately 2 percent of cerebral gliomas. They are typically slow-growing neoplasms that occur mainly in children, with 90 percent diagnosed before the age of 20 and 75 percent before the age of 10 .
Optic pathway gliomas (OPGs) are classified by anatomic location and by whether or not they are associated with neurofibromatosis type 1 (NF1, von Recklinghausen's disease).
Location — Low-grade gliomas may involve the anterior visual pathway of the optic nerve (25 to 35 percent of cases) or the posterior visual pathways (chiasmal and postchiasmal).
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- - Anterior visual pathway
- - Posterior visual pathway
- Association with neurofibromatosis
- CLINICAL PRESENTATION
- CLINICAL COURSE AND PROGNOSIS
- Optic nerve tumors
- Posterior tumors
- - Tumor resection
- - Radiotherapy
- - Chemotherapy
- SUMMARY AND RECOMMENDATIONS
- Anterior pathway lesions
- Chiasmal and hypothalamic tumors