Medline ® Abstracts for References 3,7,10
of 'Nonbacterial thrombotic endocarditis'
Non-bacterial thrombotic endocarditis in cancer patients.
González Quintela A, Candela MJ, Vidal C, Román J, Aramburo P
Acta Cardiol. 1991;46(1):1.
A total of 10 cases of non-bacterial thrombotic endocarditis (NBTE) were found among 1640 adult patients, autopsied in a 24-year period. Eight out of 10 patients had an underlying malignant tumor, NBTE was more common in cancer patients than in patients without malignancy (1.25% vs 0.2%, P less than 0.05). Patients with adenocarcinoma were at higher risk than patients with other malignant processes (2.70% vs 0.47%, P less than 0.05); especially in cases of pancreatic cancer in comparison with other kinds of adenocarcinoma (10.34% vs 1.55%, P less than 0.05). Systemic embolization was the main cause of morbidity. Any thromboembolic event in cancer patients should prompt a search for NBTE. NBTE may be present in undisseminated cancers in otherwise curable patients.
Department of Medicine, Clinica Puerta de Hierro.
Nonbacterial thrombotic endocarditis in cancer patients: pathogenesis, diagnosis, and treatment.
el-Shami K, Griffiths E, Streiff M
Oncologist. 2007 May;12(5):518-23.
Thrombophilia is a well-described consequence of cancer and its treatment. The pathogenesis of this phenomenon is complex and multifactorial. Nonbacterial thrombotic endocarditis (NBTE) is a serious and potentially underdiagnosed manifestation of this prothrombotic state that can cause substantial morbidity in affected patients, most notably recurrent or multiple ischemic cerebrovascular strokes. Diagnosis of NBTE requires a high degree of clinical suspicion as well as the judicious use of two-dimensional echocardiography to document the presence of valvular thrombi. In the absence of contraindications to therapy, treatment consists of systemic anticoagulation, which may ameliorate symptoms and prevent further thromboembolic episodes, as well as control of the underlying malignancy whenever possible.
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA. firstname.lastname@example.org
Recurrent embolism in the course of marantic endocarditis.
Borowski A, Ghodsizad A, Cohnen M, Gams E
Ann Thorac Surg. 2005 Jun;79(6):2145-7.
Marantic or nonbacterial thrombotic endocarditis (NBTE) associated with systemic embolism is usually a complication of advanced or terminal malignancies. We report on the case of a 46-year-old woman in whom nonbacterial thrombotic endocarditis (NBTE)-related cerebral embolism was the first clinical sign of ovarian neoplasm, which was diagnosed after cardiac surgery. Marantic endocarditis should alert the physician to make every effort to diagnose the possible background of this clinical phenomenon. Early identification of NBTE, treatment of the underlying disease, and the associated coagulopathy could possibly prevent cardiac surgery.
Department of Thoracic and Cardiovascular Surgery, Institute of Diagnostic Radiology, University of Düesseldorf, Düesseldorf, Germany. email@example.com