Medline ® Abstract for Reference 36
of 'Nonarteritic ischemic optic neuropathy: Prognosis and treatment'
Biomechanical assessment of radial optic neurotomy.
Friberg TR, Smolinski P, Hill S, Kurup SK
Ophthalmology. 2008;115(1):174. Epub 2007 Jun 4.
PURPOSE: A biomechanical model was constructed to simulate the potential therapeutic effect that the surgical procedure radial optic neurotomy (RON) would have on an eye with a central retinal vein occlusion.
DESIGN: Experimental study.
CONTROLS: Model eyes undergoing RON were compared to control eyes under the same baseline conditions.
INTERVENTION: Radial optic neurotomy. We modeled the optic nerve, lamina cribrosa, and the sclera separately and then reassembled the components. Material properties of the sclera and lamina cribrosa were extracted from the literature and both stiff and more elastic values were used for the optic nerve. Intraocular and arterial pressures were varied across a wide range in the analysis.
MAIN OUTCOME MEASURE: Change in central retinal vein lumen size.
RESULTS: Over a clinically relevant range of boundary conditions, the increase in the lumen area of the central retinal vein lumen after RON remained trivial, ranging from 1% to a maximum of 5%.
CONCLUSIONS: The biomechanical effect of RON is negligible, and is unlikely to be a procedure that could mechanically ameliorate the clinical sequelae of a central vein occlusion.
Department of Ophthalmology, University of Pittsburgh School of Medicine, UPMC Eye Center, Pittsburgh, Pennsylvania 15213, USA. email@example.com