Medline ® Abstracts for References 53,54
of 'Nocturnal enuresis in children: Management'
Comparison of urodynamic findings and response to oxybutynin in nocturnal enuresis.
Persson-Jünemann C, Seemann O, Köhrmann KU, Jünemann KP, Alken P
Eur Urol. 1993;24(1):92.
Sixty-three children with persistent nocturnal enuresis were urodynamically assessed and subsequently treated with oxybutynin chloride. Urodynamic evaluation, including graduation of detrusor instability and comparison of maximum bladder capacity with the age-predicted norm, confirmed an inadequate storage function in 84% of the children. Treatment benefit totaling 70% was dependent upon urodynamic findings, with best relation to the determined bladder capacity. The value attributed to graduation of uninhibited contractions was prognostic in accordance with further subdivision of the maximum bladder capacity. Treatment benefit was limited in children with normal urodynamic findings.
Department of Urology, Mannheim Hospital, School of Medicine, University of Heidelberg, FRG.
Oxybutynin efficacy in the treatment of primary enuresis.
Lovering JS, Tallett SE, McKendry JB
The effectiveness of oxybutynin in the treatment of primary enuresis was evaluated in a double-blind study. A total of 30 children (25 boys, five girls), at least 6 years of age, with primary enuresis and no daytime incontinence or history of other urinary tract problems were selected at random from an enuresis clinic population. The study was explained to the families and they were told how to keep records of nocturnal bed-wetting episodes and side effects. The patients were treated with a 10 mg of oxybutynin at suppertime for 28 days. Before or after the treatment period, all children received an identical placebo for 4 weeks. Two-sided paired t tests were used to compare frequency of nocturnal enuresis. Frequency during the drug regimen did not differ significantly from that during the placebo study. There were no differences in findings between boys and girls or between children who had previously taken imipramine and those who had not. The study showed no evidence that oxybutynin is effective in treating primary enuresis.
Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.