Medline ® Abstract for Reference 30
of 'Neuroleptic malignant syndrome'
30
TI
Prospective evaluation of circulatory levels of catecholamines and serotonin in neuroleptic malignant syndrome.
AU
Spivak B, Maline DI, Vered Y, Kozyrev VN, Mester R, Neduva SA, Ravilov RS, Graff E, Weizman A
SO
Acta Psychiatr Scand. 2000;102(3):226.
OBJECTIVE:
Neuroleptic malignant syndrome (NMS) may be associated with a dysregulation of the catecholaminergic and serotonergic systems. The objective of the present study was to evaluate prospectively the circulatory levels of serotonin (5-HT), epinephrine (E) and dopa in patients suffering from NMS.
METHOD:
Platelet-poor plasma (PPP) levels of serotonin, epinephrine and dopa in eight NMS patients were measured twice: in the acute state and in the state of remission.
RESULTS:
PPP dopa concentration was significantly lower in acute NMS state compared to the remission state (P = 0.023). In contrast, PPP E level was significantly higher (P = 0.019) in the acute NMS state and PPP 5-HT concentrations in the acute state tended to be higher than those at remission (P = 0.078). 5-HT/dopa ratio was significantly higher in the acute NMS (P = 0.015).
CONCLUSION:
These results may reflect reduction in dopaminergic function and increase in adrenergic and serotonergic activity inthe acute NMS state.
AD
Research Unit, Ness-Ziona Mental Health Center, Israel.
PMID