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Nerve conduction studies: Late responses

Steven H Horowitz, MD
Section Editor
Jeremy M Shefner, MD, PhD
Deputy Editor
John F Dashe, MD, PhD


The unique natural electrical properties of peripheral nerves can be evaluated in health and disease with externally applied stimuli and analysis of the consequent neurophysiologic responses. Nerve conduction study techniques permit stimulation and recording of electrical activity from individual peripheral nerves with sufficient accuracy, reproducibility, and standardization to determine normal values, characterize abnormal findings, and correlate neurophysiologic-pathologic features.

These clinical studies are used to:

Diagnose focal and generalized disorders of peripheral nerves

Classify peripheral nerve conduction abnormalities due to axonal degeneration, demyelination, and conduction block

Prognosticate regarding clinical course and efficacy of treatment

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Literature review current through: Dec 2017. | This topic last updated: Dec 19, 2016.
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  1. Kimura J. Electrodiagnosis in Diseases of Nerve and Muscle, 3rd ed, Oxford University Press, Oxford 2001.
  2. Dumitru D. Electrodiagnostic Medicine, Hanlye & Belfus, Philadelphia 1995.
  3. Nandedkar SD, Barkhaus PE. Tibial nerve F-wave recordings. Muscle Nerve 2015; 52:997.
  4. Young MS, Triggs WJ. Effect of stimulator orientation on F-wave persistence. Muscle Nerve 1998; 21:1324.
  5. Fisher MA. F-waves--physiology and clinical uses. ScientificWorldJournal 2007; 7:144.
  6. Pan H, Jian F, Lin J, et al. F-wave latencies in patients with diabetes mellitus. Muscle Nerve 2014; 49:804.
  7. Fisher MA. F-waves in diabetes mellitus: Answers and questions. Muscle Nerve 2014; 49:783.
  8. Jerath NU, Aul E, Reddy CG, et al. Prolongation of F-wave minimal latency: a sensitive predictor of polyneuropathy. Int J Neurosci 2015.
  9. Kiers L, Clouston P, Zuniga G, Cros D. Quantitative studies of F responses in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. Electroencephalogr Clin Neurophysiol 1994; 93:255.
  10. Research criteria for diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP). Report from an Ad Hoc Subcommittee of the American Academy of Neurology AIDS Task Force. Neurology 1991; 41:617.
  11. Van den Bergh PY, Piéret F. Electrodiagnostic criteria for acute and chronic inflammatory demyelinating polyradiculoneuropathy. Muscle Nerve 2004; 29:565.
  12. Andersen H, Stålberg E, Falck B. F-wave latency, the most sensitive nerve conduction parameter in patients with diabetes mellitus. Muscle Nerve 1997; 20:1296.
  13. American Association of Neuromuscular & Electrdiagnostic Medicine (AANEM). Proper performance and interpretation of electrodiagnostic studies. Muscle Nerve 2006; 33:436.
  14. Falco FJ, Hennessey WJ, Goldberg G, Braddom RL. H reflex latency in the healthy elderly. Muscle Nerve 1994; 17:161.
  15. Cho SC, Ferrante MA, Levin KH, et al. Utility of electrodiagnostic testing in evaluating patients with lumbosacral radiculopathy: An evidence-based review. Muscle Nerve 2010; 42:276.
  16. Misiaszek JE. The H-reflex as a tool in neurophysiology: its limitations and uses in understanding nervous system function. Muscle Nerve 2003; 28:144.
  17. Kumru H, Albu S, Valls-Sole J, et al. Influence of spinal cord lesion level and severity on H-reflex excitability and recovery curve. Muscle Nerve 2015; 52:616.
  18. Feyissa AM, Tummala S. Intraoperative neurophysiologic monitoring with Hoffmann reflex during thoracic spine surgery. J Clin Neurosci 2015; 22:990.