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Nephrolithiasis during pregnancy

Glenn M Preminger, MD
Gary C Curhan, MD, ScD
Section Editors
Stanley Goldfarb, MD
Charles J Lockwood, MD, MHCM
Deborah Levine, MD
Deputy Editor
Albert Q Lam, MD


The development of a symptomatic stone during pregnancy is a rare event, occurring in approximately one in every 1500 to 3000 pregnancies [1,2]. This rate is similar to nonpregnant women of childbearing age [3].


Affected patients usually present in the second or third trimester (approximately 20 percent in the first trimester) with acute flank pain (90 percent), which often radiates to the groin or lower abdomen. Hematuria is present in 75 to 95 percent, one-third of whom have gross hematuria, and approximately 40 percent will have pyuria [1,2].

Most of these women do not have a prior history of stone disease [2]. However, it is not clear whether such women have a preexisting stone, an underlying tendency to stone formation, or whether factors related to pregnancy are responsible. Normal pregnancy is associated with an increase in urine calcium excretion (243 versus 194 mg/day in one series), lesser increases in urine citrate and magnesium excretion (which protect against stone formation), and a rise in urine pH but not urine volume [4]. The urine supersaturation for calcium oxalate is similar to that in nonpregnant women with calcium stones. Additional factors that contribute to stone formation during pregnancy may include urinary stasis, secondary to increased progesterone levels and diminished fluid intake during late pregnancy, as a result of decreasing bladder capacity from the gravid uterus. In a study of 27 patients who had a procedure to have their stones removed, the composition in 20 was predominantly calcium phosphate [5].


Renal and pelvic ultrasound should be performed when an obstructing calculus is suspected [2]. This modality avoids exposure to radiation and is useful for detecting secondary signs of obstruction, such as hydronephrosis or hydroureter (image 1). However, physiological hydronephrosis of pregnancy must be distinguished from pathological hydronephrosis from obstruction (image 2) (see "Maternal adaptations to pregnancy: Renal and urinary tract physiology"). Rarely, pelvic ultrasound may identify a stone obstructing the distal ureter (image 3) [6].

The ability of ultrasonography and other imaging modalities to detect nephrolithiasis was retrospectively evaluated in a study of 57 pregnant women with 73 admissions for symptomatic nephrolithiasis [2]. When performed as the initial examination, renal ultrasonography detected calculi in 21 of 35 cases (60 percent sensitivity).

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Literature review current through: Oct 2017. | This topic last updated: Aug 29, 2017.
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