Multiple system atrophy: Prognosis and treatment
- Stewart A Factor, DO
Stewart A Factor, DO
- Professor, Department of Neurology
- Director, Movement Disorders Program
- Emory University School of Medicine
- Christine Doss Esper, MD
Christine Doss Esper, MD
- Assistant Professor, Department of Neurology
- Movement Disorders & Deep Brain Stimulation Program
- Emory University School of Medicine
Multiple system atrophy (MSA) is a unifying term that brings together a group of neurodegenerative disorders (olivopontocerebellar atrophy, striatonigral degeneration, and Shy-Drager) characterized by various degrees of autonomic dysfunction, cerebellar abnormalities, parkinsonism, and corticospinal degeneration.
This topic will review the prognosis and management of MSA. Other clinical aspects of MSA are reviewed separately. (See "Multiple system atrophy: Clinical features and diagnosis".)
Disease progression in MSA usually occurs over one to 18 years, and is often faster than that of idiopathic Parkinson disease .
In mainly retrospective studies, the median times from disease onset to disability milestones in MSA were as follows:
●Development of autonomic dysfunction, 2.5 years 
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