Multifocal motor neuropathy
- Dale Lange, MD
Dale Lange, MD
- Professor of Neurology
- Weill College of Medicine at Cornell University
- Jessica Robinson-Papp, MD
Jessica Robinson-Papp, MD
- Assistant Professor
- Icahn School of Medicine at Mount Sinai
Multifocal motor neuropathy (MMN), also known as multifocal motor neuropathy with conduction block, is a rare neuropathy characterized by progressive asymmetric weakness and atrophy without sensory abnormalities, a presentation similar to that of motor neuron disease. This review will discuss the clinical aspects of MMN. Other immune-mediated neuropathies are discussed separately. (See "Immune-mediated neuropathies".)
MMN is considered an immune-mediated disorder given the following observations [1-3]:
●Clinical improvement with intravenous immune globulin therapy
●The presence of anti-GM1 antibodies in many but not all patients
●A perivascular lymphocytic infiltration observed on nerve biopsy in some reports
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