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Medline ® Abstract for Reference 70

of 'Molecular genetics of colorectal cancer'

Liver-directed viral therapy for cancer p53-targeted adenoviruses and beyond.
Warren RS, Kirn DH
Surg Oncol Clin N Am. 2002;11(3):571.
Loss of p53 function is one of the most frequent genetic alterations in human cancers. Both replication-incompetent (rAd.p53, or SCH58500) and replication-selective (dl1520, or Onyx-015) adenoviruses are being developed for the treatment of p53-deficient cancers. Hepatic arterial infusion (HAI) has historically been used to selectively target colorectal tumors within the liver; consequently, regional therapy with adenovirus in this setting is an attractive approach. This article reviews Phase I and I/II HAI trial results with these adenovirus constructs.
Department of Surgery, University of California-San Francisco, 533 Parnassus Avenue, U-372, San Francisco, CA 94143-0790, USA. warrenr@surgery.ucsf.edu