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Medline ® Abstract for Reference 31

of 'Molecular genetics of colorectal cancer'

31
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The GTPase superfamily: conserved structure and molecular mechanism.
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Bourne HR, Sanders DA, McCormick F
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Nature. 1991;349(6305):117.
 
GTPases are conserved molecular switches, built according to a common structural design. Rapidly accruing knowledge of individual GTPases--crystal structures, biochemical properties, or results of molecular genetic experiments--support and generate hypotheses relating structure to function in other members of the diverse family of GTPases.
AD
Department of Pharmacology, University of California, San Francisco 94143-0450.
PMID