Medline ® Abstract for Reference 18
of 'Molecular biology and pathogenesis of von Hippel-Lindau disease'
The primary cilium: keeper of the key to cell division.
Pan J, Snell W
Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.
Department of Biological Sciences and Technologies, Tsinghua University, Haidian District, Beijing, 100084, China.