Minor wound repair with tissue adhesives (cyanoacrylates)
- Susan Lipsett, MD
Susan Lipsett, MD
- Instructor in Pediatrics
- Harvard Medical School
- Section Editors
- Anne M Stack, MD
Anne M Stack, MD
- Section Editor — Pediatric Procedures
- Associate Professor, Department of Pediatrics
- Harvard Medical School
- Allan B Wolfson, MD
Allan B Wolfson, MD
- Section Editor — Adult Procedures
- Professor of Emergency Medicine
- University of Pittsburgh
- Deputy Editor
- James F Wiley, II, MD, MPH
James F Wiley, II, MD, MPH
- Senior Deputy Editor — UpToDate
- Deputy Editor — Adult and Pediatric Emergency Medicine
- Deputy Editor — Primary Care Sports Medicine (Adolescents and Adults)
- Clinical Professor of Pediatrics and Emergency Medicine/Traumatology
- University of Connecticut School of Medicine
Laceration repair with tissue adhesives is discussed here. Repair of surgical incisions with tissue adhesives and information concerning wound preparation and irrigation, topical and infiltrative anesthesia, and wound closure with sutures or staples is found separately as follows:
- Capellan O, Hollander JE. Management of lacerations in the emergency department. Emerg Med Clin North Am 2003; 21:205.
- Bruns TB, Worthington JM. Using tissue adhesive for wound repair: a practical guide to dermabond. Am Fam Physician 2000; 61:1383.
- Pearson AS, Wolford RW. Management of skin trauma. Prim Care 2000; 27:475.
- Singer AJ, Quinn JV, Hollander JE. The cyanoacrylate topical skin adhesives. Am J Emerg Med 2008; 26:490.
- Toriumi DM, Bagal AA. Cyanoacrylate tissue adhesives for skin closure in the outpatient setting. Otolaryngol Clin North Am 2002; 35:103.
- Yamamoto LG. Preventing adverse events and outcomes encountered using dermabond. Am J Emerg Med 2000; 18:511.
- Hollander JE. Use of tissue adhesives in laceration repair. In: Textbook of Pediatric Emergency Procedures, 2nd edition, King C, Henretig FM (Eds), Lippincott, Williams, & Wilkins, Philadelphia 2008. p.1045.
- Perron AD, Garcia JA, Parker Hays E, Schafermeyer R. The efficacy of cyanoacrylate-derived surgical adhesive for use in the repair of lacerations during competitive athletics. Am J Emerg Med 2000; 18:261.
- Honsik KA, Romeo MW, Hawley CJ, et al. Sideline skin and wound care for acute injuries. Curr Sports Med Rep 2007; 6:147.
- Farion K, Osmond MH, Hartling L, et al. Tissue adhesives for traumatic lacerations in children and adults. Cochrane Database Syst Rev 2002; :CD003326.
- Osmond MH, Quinn JV, Sutcliffe T, et al. A randomized, clinical trial comparing butylcyanoacrylate with octylcyanoacrylate in the management of selected pediatric facial lacerations. Acad Emerg Med 1999; 6:171.
- Singer AJ, Giordano P, Fitch JL, et al. Evaluation of a new high-viscosity octylcyanoacrylate tissue adhesive for laceration repair: a randomized, clinical trial. Acad Emerg Med 2003; 10:1134.
- Man SY, Wong EM, Ng YC, et al. Cost-consequence analysis comparing 2-octyl cyanoacrylate tissue adhesive and suture for closure of simple lacerations: a randomized controlled trial. Ann Emerg Med 2009; 53:189.
- Handschel JG, Depprich RA, Dirksen D, et al. A prospective comparison of octyl-2-cyanoacrylate and suture in standardized facial wounds. Int J Oral Maxillofac Surg 2006; 35:318.
- Singer AJ, Chale S, Giardano P, et al. Evaluation of a novel wound closure device: a multicenter randomized controlled trial. Acad Emerg Med 2011; 18:1060.
- Osmond MH, Klassen TP, Quinn JV. Economic comparison of a tissue adhesive and suturing in the repair of pediatric facial lacerations. J Pediatr 1995; 126:892.
- Singer AJ, Thode HC Jr. A review of the literature on octylcyanoacrylate tissue adhesive. Am J Surg 2004; 187:238.
- Kazzi MG, Silverberg M. Pediatric tongue laceration repair using 2-octyl cyanoacrylate (dermabond(®)). J Emerg Med 2013; 45:846.
- Edmonson MB. Foreign body reactions to dermabond. Am J Emerg Med 2001; 19:240.
- Harman S, Zemek R, Duncan MJ, et al. Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial. CMAJ 2013; 185:E629.
- Quinn J, Wells G, Sutcliffe T, et al. A randomized trial comparing octylcyanoacrylate tissue adhesive and sutures in the management of lacerations. JAMA 1997; 277:1527.
- Singer AJ, Hollander JE, Valentine SM, et al. Prospective, randomized, controlled trial of tissue adhesive (2-octylcyanoacrylate) vs standard wound closure techniques for laceration repair. Stony Brook Octylcyanoacrylate Study Group. Acad Emerg Med 1998; 5:94.
- Histoacryl and Histoacryl Blue topical skin adhesive package insert. 2007. http://www.accessdata.fda.gov/cdrh_docs/pdf5/P050013c.pdf (Accessed on July 30, 2013).
- Hollander JE, Singer AJ. Laceration management. Ann Emerg Med 1999; 34:356.
- Resch KL, Hick JL. Preliminary experience with 2-octylcyanoacrylate in a pediatric emergency department. Pediatr Emerg Care 2000; 16:328.
- Coutts SJ, Sandhu R, Geh VS. Tissue glue and iatrogenic eyelid gluing in children. Pediatr Emerg Care 2012; 28:810.
- Yeilding RH, O'Day DM, Li C, et al. Periorbital infections after Dermabond closure of traumatic lacerations in three children. J AAPOS 2012; 16:168.
- PROPERTIES OF TISSUE ADHESIVES
- CONTRAINDICATIONS AND PRECAUTIONS
- Wound preparation
- Patient positioning
- 2-octyl-cyanoacrylate (eg, Dermabond or Surgiseal)
- n-butyl-2-cyanoacrylate (eg, Histoacryl Blue or Periacryl)
- Excess leakage
- Gluing of gloves or instruments
- Ocular exposure
- Wound infection
- SUMMARY AND RECOMMENDATIONS