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Middle East respiratory syndrome coronavirus: Clinical manifestations and diagnosis

Author
Kenneth McIntosh, MD
Section Editor
Martin S Hirsch, MD
Deputy Editor
Anna R Thorner, MD

INTRODUCTION

In September 2012, a case of novel coronavirus infection was reported involving a man in Saudi Arabia who was admitted to a hospital with pneumonia and acute kidney injury in June 2012 [1]. Only a few days later, a separate report appeared of an almost identical virus detected in a second patient with acute respiratory syndrome and acute kidney injury [2,3]. The second patient initially developed symptoms in Qatar but had traveled to Saudi Arabia before he became ill and then sought care in the United Kingdom [4]. Many subsequent cases and clusters of infections have been reported.

This novel coronavirus, initially termed human coronavirus-EMC (for Erasmus Medical Center), has been named Middle East respiratory syndrome coronavirus (MERS-CoV) [5].

Updated information about MERS-CoV can be found on the World Health Organization's website and the United States Centers for Disease Control and Prevention's website.

The clinical manifestations and diagnosis of MERS-CoV are discussed here. The virology, epidemiology, treatment, and prevention of MERS-CoV are discussed separately. Community-acquired coronaviruses and severe acute respiratory syndrome coronavirus are also reviewed separately. (See "Middle East respiratory syndrome coronavirus: Virology, pathogenesis, and epidemiology" and "Middle East respiratory syndrome coronavirus: Treatment and prevention" and "Coronaviruses" and "Severe acute respiratory syndrome (SARS)".)

CASE DEFINITIONS

For epidemiologic purposes, the following Middle East respiratory syndrome coronavirus (MERS-CoV) infection case definitions have been proposed by the World Health Organization (WHO) [6]:

                      

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Literature review current through: Nov 2016. | This topic last updated: Mon Jul 25 00:00:00 GMT+00:00 2016.
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