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Medline ® Abstract for Reference 48

of 'Medical management of gastroesophageal reflux disease in adults'

48
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Comparison of cimetidine (Tagamet) with antacid for safety and effectiveness in reducing gastric acidity before elective cesarean section.
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Hodgkinson R, Glassenberg R, Joyce TH 3rd, Coombs DW, Ostheimer GW, Gibbs CP
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Anesthesiology. 1983;59(2):86.
 
One hundred twenty-six parturients for elective cesarean section under general anesthesia were allocated to either a cimetidine or an antacid group in a randomized, double-blind, multicenter trial. The cimetidine-treated group received 300 mg cimetidine orally the evening before the operation and 300 mg intramuscularly between 1 and 3 h preoperatively. The antacid-treated group received 30 ml of Mylanta-II orally on both occasions. Gastric volume, 30 min after induction of anesthesia and 30 min before response to oral commands, was less in the cimetidine-treated group. Gastric pH 30 min after induction was greater in the cimetidine-treated group. The maternal serum level of cimetidine at birth was 1.31 +/- 0.12 micrograms/ml and the umbilical venous level was 0.78 +/- 0.05 micrograms/ml. The neonatal gastric acidity, Apgar scores, and Early Neonatal Neurobehavioral Scale (ENNS) scores were similar in both groups. No maternal or neonatal complication was attributed to treatment.
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PMID