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Management of warfarin-associated bleeding or supratherapeutic INR

Russell D Hull, MBBS, MSc
David A Garcia, MD
Section Editor
Lawrence LK Leung, MD
Deputy Editor
Jennifer S Tirnauer, MD


Warfarin is associated with an increased risk of bleeding, as are a variety of other anticoagulants. The effect of warfarin has great inter- and intra-individual variation based on a variety of genetic, dietary, and medication effects. This topic discusses risk factors for warfarin-associated bleeding and poor international normalized ratio (INR) control and presents an approach to the management of a patient with these complications.

The following special populations are discussed in separate topic reviews:

Intracerebral hemorrhage – (See "Reversal of anticoagulation in warfarin-associated intracerebral hemorrhage".)

Surgery/invasive procedure – (See "Perioperative management of patients receiving anticoagulants".)

Patient with a prosthetic heart valve – (See "Antithrombotic therapy in patients with prosthetic heart valves".)


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Literature review current through: Oct 2015. | This topic last updated: Nov 13, 2015.
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