Management of stress ulcers
- David W Mercer, MD
David W Mercer, MD
- Associate Professor of Surgery, Transplant
- University of Nebraska Medical Center
- Matthew R Goede, MD
Matthew R Goede, MD
- Assistant Professor
- Department of Surgery
- University of Nebraska Medical Center
Stress ulcers were once a major cause of morbidity and mortality in critically ill patients. However, with the advent of ulcer prophylaxis and improved critical care, surgical intervention is only necessary for a small number of patients with life-threatening hemorrhage or perforation from stress ulcers .
The nonsurgical management, indications for surgery, and surgical management of patients with stress ulcers are reviewed here. The epidemiology, pathogenesis, clinical manifestations, and prophylaxis of stress ulcers, as well as the nonsurgical treatments of upper gastrointestinal bleeding are discussed elsewhere. (See "Stress ulcer prophylaxis in the intensive care unit" and "Approach to acute upper gastrointestinal bleeding in adults".)
The surgical treatment of peptic ulcer disease (not stress ulcer disease) is presented separately. (See "Surgical management of peptic ulcer disease".)
Stress gastritis may be referred to as diffuse mucosal injury, stress-related mucosal disease, stress ulceration, hemorrhagic gastritis, erosive gastritis, Curling's ulcer, and Cushing's ulcer. Stress-related erosive syndrome was first described in 1971 . A commonality to all is the presence of multiple superficial erosions of the gastric mucosa, beginning in the proximal acid-secreting portion of the stomach and progressing distally. Cushing's ulcers develop following central nervous system injury. Morphologically, Cushing's ulcers tend to be single and deep and may involve the esophagus, stomach, or duodenum . Curling's ulcers occur following burns involving greater than 30 percent total body surface area. Curling's ulcers can occur in the stomach or duodenum . Stress gastritis erosions occur after physical trauma, shock, hemorrhage, and sepsis. Thus, stress gastritis represents end-organ failure of the stomach in critical illness.
Stress gastritis erosions can be identified within hours following injury and occur nearly universally (in the absence of prophylaxis) following severe shock . These erosions appear as wedge-shaped mucosal hemorrhages with necrosis of the superficial mucosal cells. If these erosions continue to progress and extend into the submucosa, significant and life-threatening bleeding may arise. The pathogenesis of stress gastritis is presented elsewhere. (See "Stress ulcer prophylaxis in the intensive care unit", section on 'Pathophysiology'.)To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- INITIAL MANAGEMENT
- Correction of coagulopathy
- Nasogastric tube placement
- Antisecretory agents
- INDICATIONS FOR SURGERY
- Refractory bleeding
- - Bleeding causing hemodynamic instability
- - Stable patients with persistent blood loss complicating comorbid conditions
- Gastrointestinal perforation
- PREOPERATIVE PREPARATION
- SURGICAL ANATOMY
- Blood supply
- Vagal innervation
- SURGICAL APPROACH
- Abdominal incision and exploration
- Anterior gastrotomy and oversewing of bleeders
- Subsequent approach based upon hemodynamic stability
- - Stable patients
- Vagotomy and drainage procedure
- - Unstable patients
- Rarely performed procedures
- - Gastric resection procedures
- Partial gastrectomy
- Subtotal or total gastrectomy
- - Gastric devascularization
- POSTOPERATIVE CARE
- FOLLOW-UP CARE
- MORBIDITY AND MORTALITY
- SUMMARY AND RECOMMENDATIONS