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Management of pregnancy complicated by Rhesus (D) alloimmunization

Kenneth J Moise Jr, MD
Section Editor
Charles J Lockwood, MD, MHCM
Deputy Editor
Vanessa A Barss, MD, FACOG


Despite the development and implementation of anti-D immune globulin prophylaxis, hemolytic disease of the fetus and newborn due to maternal Rh(D) alloimmunization continues to occur worldwide. Ideally, pregnancies complicated by alloimmunization should be managed by a maternal-fetal medicine specialist with appropriate experience and credentialed to perform the invasive diagnostic and therapeutic procedures that may be needed. With appropriate pregnancy monitoring and intervention, this disorder can be treated successfully in almost all cases, with minimal long-term sequelae in offspring.

This topic will provide our approach to management of pregnant women with Rh(D) alloimmunization. Related topics, including a discussion of the Rhesus system, diagnosis and prevention of Rh(D) alloimmunization, diagnosis and management of pregnant women with non-Rh(D) alloimmunization, in utero transfusion, and neonatal issues, are reviewed in detail separately:

(See "Overview of Rhesus D alloimmunization in pregnancy".)

(See "Management of non-Rhesus (D) red blood cell alloantibodies during pregnancy".)

(See "Intrauterine fetal transfusion of red cells".)

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Literature review current through: Nov 2017. | This topic last updated: Aug 29, 2017.
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