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Medline ® Abstract for Reference 63

of 'Management of patients at high risk for breast and ovarian cancer'

63
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The role of BRCA mutation testing in determining breast cancer therapy.
AU
Trainer AH, Lewis CR, Tucker K, Meiser B, Friedlander M, Ward RL
SO
Nat Rev Clin Oncol. 2010;7(12):708. Epub 2010 Nov 9.
 
Landmark discoveries in the field of breast cancer research include the identification of germline BRCA mutations as a cause of hereditary disease, and the use of gene-expression profiling to identify distinct subtypes of breast cancer. These findings, coupled with the availability of rapid germline testing, make it possible to identify a BRCA mutation carrier contemporaneous with a diagnosis of breast cancer. For the first time, testing for a germline mutation that predisposes to cancer has the potential to influence the immediate surgical, radiotherapeutic, and drug treatment choices of an individual with a new diagnosis of breast cancer. In this Review, we examine the implications of moving germline BRCA mutation testing from highly specialized family cancer clinics to mainstream settings.
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Jack Brockhoff Familial Cancer Centre, Peter MacCallum Cancer Centre, 10 St Andrews Place, East Melbourne, VIC 3002, Australia.
PMID