Medline ® Abstract for Reference 87
of 'Management of gastrointestinal lymphomas'
Combination chemotherapy followed by autologous stem cell transplant for enteropathy-associated T cell lymphoma.
Bishton MJ, Haynes AP
Br J Haematol. 2007;136(1):111. Epub 2006 Nov 20.
Enteropathy-associated T cell lymphoma (EATL) is a rare entity associated with coeliac disease, with a poor prognosis due to perforation and gastro-intestinal bleeding during treatment, and a high relapse risk. Six patients were treated with two cycles of IVE (ifosphamide, etoposide, epirubicin), followed by two cycles of high-dose methotrexate (3 g/m(2)) with folinic acid rescue and a BEAM (carmustine, etoposide, cytarabine, melphalan) autograft. Enteral feeding was given throughout treatment. Four patients remain alive in complete remission at 1.83-4.32 years; two have relapsed. Given the historically poor outcome in these patients, this regimen appears very promising in the treatment of EATL.
Department of Haematology, Nottingham City Hospital, Nottingham, UK.