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Medline ® Abstract for Reference 87

of 'Management of gastrointestinal lymphomas'

87
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Combination chemotherapy followed by autologous stem cell transplant for enteropathy-associated T cell lymphoma.
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Bishton MJ, Haynes AP
SO
Br J Haematol. 2007;136(1):111. Epub 2006 Nov 20.
 
Enteropathy-associated T cell lymphoma (EATL) is a rare entity associated with coeliac disease, with a poor prognosis due to perforation and gastro-intestinal bleeding during treatment, and a high relapse risk. Six patients were treated with two cycles of IVE (ifosphamide, etoposide, epirubicin), followed by two cycles of high-dose methotrexate (3 g/m(2)) with folinic acid rescue and a BEAM (carmustine, etoposide, cytarabine, melphalan) autograft. Enteral feeding was given throughout treatment. Four patients remain alive in complete remission at 1.83-4.32 years; two have relapsed. Given the historically poor outcome in these patients, this regimen appears very promising in the treatment of EATL.
AD
Department of Haematology, Nottingham City Hospital, Nottingham, UK.
PMID