Troponin testing: Clinical use
- Allan S Jaffe, MD
Allan S Jaffe, MD
- Section Editor — Coronary Heart Disease
- Professor of Medicine
- Mayo Medical School
- David A Morrow, MD, MPH
David A Morrow, MD, MPH
- Professor of Medicine
- Harvard Medical School
- Section Editor
- Juan Carlos Kaski, DSc, MD, DM (Hons), FRCP, FESC, FACC, FAHA
Juan Carlos Kaski, DSc, MD, DM (Hons), FRCP, FESC, FACC, FAHA
- Section Editor — Coronary Heart Disease
- Professor of Cardiovascular Science
- Director, Cardiovascular and Cell Sciences Research Institute
- St. George's, University of London
Cardiac troponin I and cardiac troponin T are relatively specific and sensitive biomarkers of cardiac injury. They are the preferred serologic tests for the evaluation of patients with suspected acute coronary syndrome (ACS). (See "Biomarkers of cardiac injury other than troponin", section on 'Why troponin is preferred'.)
Troponin assays with varying sensitivities are available. Some contemporary assays and rare point-of-care assays are "sensitive” assays." "Highly sensitive" troponin tests are available for clinical use throughout the world but not in the United States.
This topic will focus on the role of troponin testing in the evaluation of patients with suspected ACS but will also discuss troponin testing in other cardiovascular settings (See "Evaluation of patients with chest pain at low or intermediate risk for acute coronary syndrome", section on 'Initial evaluation'.).
Analytical and technical aspects of are discussed separately. (See "Troponin testing: Analytical aspects".)
Other biomarkers of cardiac injury and other (than an acute myocardial infarction) disease states in which elevation of biomarkers are seen are discussed separately. (See "Biomarkers of cardiac injury other than troponin" and "Elevated cardiac troponin concentration in the absence of an acute coronary syndrome".)To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- POSSIBLE ACUTE MYOCARDIAL INJURY
- Suspected ACS
- - Differential diagnosis
- Use after revascularization
- Use after noncardiac surgery
- SENSITIVE COMPARED WITH HIGHLY SENSITIVE TESTS
- Pitfalls with hs assays
- AFTER MI
- Infarct size
- Prognosis after MI
- GENERAL POPULATION
- STABLE ISCHEMIC HEART DISEASE
- USE IN RENAL FAILURE