Medline ® Abstract for Reference 37
of 'Management of epilepsy and pregnancy'
37
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Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives.
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Tomson T, Luef G, Sabers A, Pittschieler S, Ohman I
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Neurology. 2006;67(7):1297.
In eight women treated with lamotrigine monotherapy, the lamotrigine dose/plasma concentration (D/C) ratio increased by 295% from baseline outside pregnancy to midgestation, whereas in six women treated with lamotrigine in combination with valproate, the increase was only 60%. No difference in lamotrigine D/C ratio was found between users and nonusers of oral contraceptives comedicated with valproate. Valproate seems to reduce the induction of lamotrigine metabolism associated with pregnancy or use of contraceptives.
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Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. torbjorn.tomson@karolinska.se
PMID