Medline ® Abstract for Reference 32
of 'Management of epilepsy and pregnancy'
32
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Individual changes in lamotrigine plasma concentrations during pregnancy.
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Petrenaite V, Sabers A, Hansen-Schwartz J
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Epilepsy Res. 2005;65(3):185.
Eleven pregnant women on lamotrigine (LTG) monotherapy were retrospectively reviewed. A significant decrease in the ratio of plasma LTG concentration-to-dose by 65.1% was observed during the second trimester (TM2) (p=0.0058) and by 65.8% during TM3 (p=0.0045) compared to pre-pregnancy values. Five patients experienced seizure deterioration during pregnancy. The pharmacokinetic changes display marked inter-patient variation, which stresses the importance of evaluating each woman individually by closely monitoring LTG concentrations until term.
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Department of Clinical Neurophysiology 3063, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. vaiva@ofir.dk
PMID