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Management of endometrial hyperplasia

Susan D Reed, MD, MPH
Renata R Urban, MD
Section Editor
Barbara Goff, MD
Deputy Editor
Sandy J Falk, MD, FACOG


The endometrium (lining of the uterus) may develop endometrial hyperplasia (EH), which includes non-neoplastic entities (disordered proliferative endometrium, benign hyperplasia, simple and complex hyperplasias without atypia) characterized by a proliferation of endometrial glands of irregular size and shape, and precancerous neoplasms (endometrial intraepithelial neoplasms [EIN], and all atypical complex hyperplasia) characterized by neoplastic features but without invasion. EH frequently results from chronic estrogen stimulation unopposed by the counterbalancing effects of progesterone [1].

Obese women and women with chronic ovulatory dysfunction (eg, polycystic ovarian syndrome) are at high risk for EH, as well as women at increased genetic risk of endometrial cancer (Lynch syndrome). The majority of women with EH present with abnormal uterine bleeding.

The management of EH is reviewed here. Related topics can be found separately:

Histopathology, classification, and diagnosis of EH (see "Classification and diagnosis of endometrial hyperplasia")

Other etiologies of abnormal uterine bleeding (see "Approach to abnormal uterine bleeding in nonpregnant reproductive-age women" and "Postmenopausal uterine bleeding")

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Literature review current through: Dec 2017. | This topic last updated: Nov 29, 2017.
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