Management of early-stage cervical cancer
- J Michael Straughn, Jr, MD
J Michael Straughn, Jr, MD
- Division of Gynecologic Oncology
- University of Alabama at Birmingham
- Catheryn Yashar, MD
Catheryn Yashar, MD
- Associate Professor of Radiation Medicine and Applied Sciences
- University of California San Diego
- Section Editors
- Barbara Goff, MD
Barbara Goff, MD
- Section Editor — Gynecologic Oncology
- Professor of Gynecologic Oncology
- University of Washington
- Arno J Mundt, MD
Arno J Mundt, MD
- Section Editor — Radiation Therapy
- Chairman of Radiation Oncology
- University of California, San Diego
- Don S Dizon, MD, FACP
Don S Dizon, MD, FACP
- Section Editor – Gynecologic Oncology
- Clinical Co-Director, Gynecologic Oncology
- Founder and Director, The Oncology Sexual Health Clinic
- Massachusetts General Hospital Cancer Center
- Associate Professor of Medicine
- Harvard Medical School
- Deputy Editors
- Sadhna R Vora, MD
Sadhna R Vora, MD
- Deputy Editor — Oncology
- Instructor in Medicine
- Harvard Medical School
- Sandy J Falk, MD, FACOG
Sandy J Falk, MD, FACOG
- Director, Editorial Relations — UpToDate
- Deputy Editor — Obstetrics, Gynecology and Women's Health
- Instructor of Obstetrics, Gynecology and Reproductive Biology, Part-time
- Harvard Medical School
Women with cervical cancer limited to the uterus have early-stage disease. Treatment options for these women include definitive surgery (modified radical hysterectomy), fertility-sparing surgery, or primary radiation therapy (RT; with or without chemotherapy). The choice of therapy depends on tumor- and patient-defined factors.
The approach to women with early-stage cervical cancers is reviewed here. Treatment of more advanced disease and specific issues regarding the management of cervical adenocarcinomas and small cell cancers are reviewed elsewhere.
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- DEFINITION OF EARLY-STAGE CERVICAL CANCER
- APPROACH TO TREATMENT
- Primary therapy
- - Surgery versus primary RT
- - Surgical treatment
- Radical hysterectomy
- Extrafascial hysterectomy or conization
- Fertility-sparing surgery
- - Primary radiation therapy
- Adjuvant therapy indications
- - Intermediate-risk disease
- Treatment of intermediate-risk disease
- - High-risk disease
- Treatment of high-risk disease
- RT technique
- POSTTREATMENT SURVEILLANCE
- QUALITY-OF-LIFE ISSUES IN CERVICAL CANCER SURVIVORS
- Ovarian failure
- Fertility preservation
- Hormone replacement therapy
- Sexual dysfunction
- SPECIAL CIRCUMSTANCES
- Incidentally diagnosed cancer
- Adenocarcinoma and small cell cancers
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS